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J Med Virol ; 93(3): 1288-1295, 2021 03.
Article in English | MEDLINE | ID: covidwho-1196477

ABSTRACT

Coronavirus disease 2019 (COVID-19) poses a serious threat to human health and lives. The virus is still spreading throughout the world, and the cumulative number of confirmed cases is increasing. After patients with COVID-19 are treated and discharged, some have repeated clinical symptoms and become positive for nucleic acid tests a second time. Through analysis and review of the existing literature, the proportion of repositive patients in the discharged patient population and their clinical characteristics were systematically described for the first time. Furthermore, an in-depth analysis of the causes of repositive nucleic acid tests and the potential transmission of the disease provides the basis for the management and protection of discharged patients with COVID-19.


Subject(s)
COVID-19/pathology , Reinfection/virology , SARS-CoV-2/pathogenicity , COVID-19/prevention & control , COVID-19 Nucleic Acid Testing , False Negative Reactions , Female , Humans , Male , Mutation , Patient Discharge , RNA, Viral , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2/genetics , Specimen Handling
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